BACKGROUND AND VISIONCardiovascular diseases arising from atherosclerosis constitute the major causes of morbidity and mortality in Sweden and are expected to be the largest group of lethal diseases globally. However, the atherosclerotic process and its complications remain enigmatic and the opportunities for prevention and therapy are limited. Against this background, we have established an internationally leading Center for Cardiovascular Disease integrating clinical, translational and basic research, education and cardiovascular care.
Our vision is to operate "from bedside to bench and back", ensuring that clinically relevant problems are addressed and that novel mechanistic insights are rapidly translated into innovative preventive, diagnostic and therapeutic approaches and implemented in clinical care. Focus will be placed on two key questions of particular clinical relevance:
(i) How can efficient prevention of plaque rupture/acute coronary syndrome be achieved?
(ii) How can the function of the ischemic myocardium be preserved and heart failure prevented?
To address these questions, we will develop new concepts for the molecular pathophysiology, prevention, diagnosis and therapy of four central processes in cardiovascular medicine - atherosclerosis, plaque rupture, myocardial ischemia including endogenous repair processes involving angiogenesis, and aneurysm formation.
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